- Anaemia
- Loss of blood from injury
- During certain surgeries
- If body cannot produce sufficient blood because of an illness
- Severe burns
- Severe infection that stops the body from properly making blood or some blood components
- Severe liver malfunction may require transfusion of albumin, blood protein
- Those undergoing radiation or Chemotherapy for cancer may require transfusion
- A bleeding disorder, such as hemophilia or thrombocytopenia (deficiency of platelets in the blood)
- Those undergoing stem cell transplants may require transfusion of red blood cells and platelets, Dengue
- Those suffering from chronic renal failure